Situated in the passage between North and Southern Europe, the region of Avignon was well whipped by the barbarian invasions.
The first wave hit at the end of the 3rd century, with the onslaught of the Franks and Alemans. It left the south with a lasting and terrible souvenir. The second, submerging wave, in the beginning of the 5th century, cut off completely the already deteriorating Roman Empire from the West.
The vandals devastated the country, followed by the Goths, then the Burgundes, who established themselves in the region. In 474 A.D., Avignon became a part of their realm, of which she was the southernmost fortification.
In these troubled times, decimated by the wars and pillaging, the inhabitants fled the villages. Avignon, like Nimes, was reduced to a seventh of its former size. What remains of the Roman city was fortified by a rapidly constructed shorter and more easily defended wall encircling the cliff where the population had taken refuge.
In the year 500, the Burgundian king, Gondebaud, pursued by the Frankish king Clovis, took refuge in Avignon. The latter did not succeed in taking the heavily fortified city. The city came under Visigoth control towards 506 A.D., followed by the Ostrogoths two years later. In 537, King Vitiges ceded Avignon and Provence to the Frankish king. The city was incorporated into the Frankish kingdom of Burgundy in 561 until the second half of the 8th century.